Statistical Methods for Detecting Differentially Abundant Features in Clinical Metagenomic Samples
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چکیده
منابع مشابه
Statistical Methods for Detecting Differentially Abundant Features in Clinical Metagenomic Samples
Numerous studies are currently underway to characterize the microbial communities inhabiting our world. These studies aim to dramatically expand our understanding of the microbial biosphere and, more importantly, hope to reveal the secrets of the complex symbiotic relationship between us and our commensal bacterial microflora. An important prerequisite for such discoveries are computational too...
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8 The use of high-throughput experiments, such as RNA-seq, to simultaneously identify 9 differentially abundant entities across conditions has become widespread, but the systematic 10 planning of such studies is currently hampered by the lack of general-purpose tools to do so. 11 Here we demonstrate that there is substantial variability in performance across statistical 12 tests, normalization ...
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ژورنال
عنوان ژورنال: PLoS Computational Biology
سال: 2009
ISSN: 1553-7358
DOI: 10.1371/journal.pcbi.1000352